Cell and Tissue Engineering (CTE)

Section Information

Cell and Tissue Engineering focuses on the development of biological substitutes, engineered tissues, and cellular systems that restore, maintain, or improve tissue function. It integrates principles from biology, engineering, materials science, and medicine to design living constructs, study cell–material interactions, and advance regenerative therapies.

Modern research in this field includes stem cell engineering, scaffold design, biomaterials, bioreactors, organoids, tissue regeneration, mechanobiology, gene editing, and biofabrication methods such as 3D bioprinting. Advances in microfluidics, synthetic biology, imaging, and computational modeling continue to expand the potential of engineered tissues and cell-based therapies.

This section publishes experimental work, engineering designs, translational studies, reviews, and methodological papers addressing cell behavior, tissue development, regenerative strategies, engineered models of disease, and innovative technologies that support biological repair and therapeutic applications.

Scope

Stem Cells and Cellular Engineering
- Embryonic, adult, and induced pluripotent stem cells
- Cell differentiation, reprogramming, and lineage specification
- Gene editing, synthetic biology, and engineered cell therapies
- Regulation of cell signaling, proliferation, and phenotype
Biomaterials and Scaffold Design
- Natural, synthetic, and hybrid biomaterials
- Scaffold architecture, biocompatibility, and degradation
- Surface engineering and biofunctionalization
- Scaffold-guided tissue repair and regeneration
Tissue Engineering and Regenerative Therapies
- Engineering of bone, cartilage, muscle, skin, vascular, and neural tissues
- Organoids, engineered microtissues, and in vitro disease models
- Cell–matrix interactions and extracellular matrix biology
- Clinical translation of tissue engineering products
Biofabrication and 3D Bioprinting
- Bioprinting technologies and bioink development
- Layer-by-layer fabrication of complex tissues
- Integration of cells, scaffolds, and signaling molecules
- Hybrid biofabrication strategies and automation
Bioreactors, Mechanobiology, and Biophysical Regulation
- Bioreactor systems for tissue culture and maturation
- Mechanical loading, shear stress, and stimulus-driven growth
- Biomechanical measurement and functional assessment
- Cellular responses to physical and mechanical cues
Microfluidics, Organ-on-Chip, and Engineered Microenvironments
- Microfluidic control of cellular microenvironments
- Organ-on-chip systems for drug screening and disease modeling
- Dynamic culture platforms for physiological simulation
- Integration of sensors and real-time monitoring
Immunoengineering and Inflammation
- Immune–cell interactions with engineered tissues
- Modulation of inflammation for tissue repair
- Engineered immune cells and immunomodulatory biomaterials
- Regenerative strategies targeting immune pathways
Translational and Clinical Applications
- Preclinical testing, safety, and regulatory considerations
- Cell-based therapies and engineered implants
- Personalized regenerative medicine and patient-specific designs
- Ethical, manufacturing, and scalability challenges