Transplantation (TRP)

Section Information

Transplantation focuses on the surgical replacement of organs, tissues, and cells to restore function in patients with end-stage disease or irreversible organ failure. It includes donor evaluation, organ preservation, immunologic compatibility, surgical techniques, and long-term recipient care.

Modern transplantation research includes advances in immunosuppression, graft tolerance, organ preservation technologies, xenotransplantation, regenerative medicine, and mechanisms of rejection. Improvements in donor management, organ allocation, and precision monitoring continue to enhance transplant outcomes and survival.

This section publishes clinical studies, basic science research, reviews, and case reports addressing transplant surgery, immunology, graft survival, postoperative complications, ethical considerations, and innovations in organ and cell-based therapies.

Scope

Solid Organ Transplantation
- Kidney, liver, heart, lung, pancreas, and intestinal transplantation
- Donor and recipient selection, evaluation, and risk assessment
- Organ preservation methods and perfusion technologies
- Post-transplant monitoring and long-term outcomes
Transplant Immunology
- Mechanisms of immune activation, tolerance, and graft rejection
- HLA matching, immunologic compatibility, and antibody-mediated injury
- Cellular and molecular pathways influencing graft survival
- Biomarkers for early detection of rejection and immune dysfunction
Immunosuppression and Pharmacotherapy
- Calcineurin inhibitors, antiproliferative agents, and biologics
- Induction, maintenance, and minimization strategies
- Drug toxicity, interactions, and therapeutic monitoring
- New immunomodulatory agents and personalized therapy
Cell, Tissue, and Stem Cell Transplantation
- Hematopoietic stem cell transplantation and cell-based therapies
- Islet cell transplantation and regenerative applications
- Tissue grafting including cornea, skin, and musculoskeletal tissues
- Advances in stem cell biology and immune modulation
Complications and Post-Transplant Management
- Acute and chronic rejection mechanisms
- Infections, malignancies, and metabolic complications
- Cardiovascular, renal, and metabolic impacts of long-term therapy
- Rehabilitation, quality of life, and long-term follow-up
Ethics, Allocation, and Health Policy
- Organ allocation systems and donor shortage challenges
- Ethical considerations in donation and transplantation
- Living donation outcomes and consent practices
- Health policy, equity, and global transplantation efforts
Xenotransplantation and Emerging Technologies
- Animal-to-human transplantation research
- Genetic modification, immunologic barriers, and safety concerns
- Organ engineering and 3D bioprinting
- Artificial organs and future transplant alternatives
Donor Science and Organ Preservation
- Deceased and living donor management
- Normothermic and hypothermic machine perfusion
- Methods to improve marginal and extended criteria organ utilization
- Strategies to reduce ischemia–reperfusion injury