Biochemistry and Molecular Biology (BMB)

Section Information

Biochemistry and Molecular Biology study the molecules and pathways that support life, from simple metabolites to complex macromolecular machines. This field explains how DNA, RNA, proteins, lipids, and carbohydrates are built, regulated, and integrated to control cell structure, function, and communication.

Modern biochemistry and molecular biology combine classic experiments with structural, biophysical, and high-throughput methods to map pathways, interactions, and regulatory networks. Approaches such as cloning, expression analysis, mutagenesis, structural analysis, and omics help link molecular changes to cellular phenotypes, health, and disease.

This section will publish research articles, short communications, and reviews on biomolecular structure and function, gene expression and regulation, signaling pathways, metabolism, molecular genetics, systems and synthetic biology, and related areas that advance our understanding of life at the molecular level.

Scope

Biomolecules: Structure and Function
- Proteins, nucleic acids, lipids, and carbohydrates
- Structure–function relationships and active sites
- Protein folding, stability, and misfolding
- Macromolecular complexes and assemblies
Enzymology and Metabolic Pathways
- Enzyme mechanisms, kinetics, and regulation
- Central and specialized metabolism in cells
- Energy transduction, redox biology, and bioenergetics
- Metabolic integration, flux, and pathway engineering
Genes, Genomes, and Gene Expression
- Genome organization and chromatin structure
- DNA replication, repair, and recombination
- Transcription, RNA processing, and translation
- Epigenetic and post-transcriptional regulation
Signal Transduction and Cellular Regulation
- Receptors, second messengers, and signaling cascades
- Post-translational modifications and protein turnover
- Cell cycle control, differentiation, and cell death
- Crosstalk between metabolic and signaling networks
Molecular Genetics and Functional Genomics
- Mutagenesis, genetic screens, and functional studies
- Transcriptomics, proteomics, and related omics
- Gene networks, regulatory circuits, and systems analysis
- Model organisms and comparative molecular studies
Structural Biology and Biophysical Methods
- Structural determination and modeling of biomolecules
- Biophysical analysis of interactions and dynamics
- Conformational changes and allostery
- Integration of structural and functional data
Molecular Cell Biology and Intracellular Organization
- Membrane systems, organelles, and trafficking
- Cytoskeleton and cell architecture
- Compartmentalization of metabolic and signaling pathways
- Molecular basis of cell–cell and cell–matrix interactions
Molecular Basis of Health and Disease
- Molecular mechanisms of genetic and metabolic disorders
- Oncogenes, tumor suppressors, and cancer signaling
- Host–pathogen molecular interactions
- Targets and mechanisms of therapeutics at molecular level
Synthetic, Systems, and Computational Biology
- Design and construction of synthetic pathways and circuits
- Quantitative and systems-level modeling of molecular networks
- Bioinformatics tools for sequence, structure, and pathway analysis
- Data integration, visualization, and predictive molecular models